Primary cutaneous gamma-delta T-cell lymphoma: Two cases and a review of the literature

Background: Primary cutaneous gamma delta T cell lymphoma (PCGD TCL) is a rare and rapidly progressive malignancy that can be diagnostically challenging. Purpose: To improve characterization of the clinical histologic features PCGD-TCL. Methods: We present two patients with PCGD TCL review an additional 97 cases from English literature. Results: A 51 year old male biopsy proven psoriasis previously healthy 31 vitiligo developed Initial specimens in both suggested tumor stage mycosis fungoides (MF), but subsequent histopathology confirmed TCL. Ninety-seven were identified literature, mostly males (53%) mean age 55.2 years. Lesions most commonly involved lower (60%) upper (30%) extremities existed 26 months before diagnosis. The common immunohistochemical markers EBV(-), CD3(+), CD4(-), CD5(-), CD7(-), CD8(-), CD30(-), CD56(+), granzyme-B(+), perforin(+), ?F1(-). Radiation CHOP chemotherapy interventions 52% died. Conclusion: devastating disease clinically histologically mimic more dermatologic conditions, such as MF, its diagnosis may require multiple biopsies by multi specialty pathology team.